Publications

Last updated: 31 December 2025

Speidell A, Agbey C, Mocchetti I. Accelerated neurodegeneration of basal forebrain cholinergic neurons in HIV-1 gp120 transgenic mice: Critical role of the p75 neurotrophin receptor. Brain Behav Immun. 2024 Mar;117:347-355. doi: 10.1016/j.bbi.2024.01.215. Epub 2024 Jan 22. PMID: 38266662

Speidell A, Bin Abid N, Yano H. Brain-Derived Neurotrophic Factor Dysregulation as an Essential Pathological Feature in Huntington’s Disease: Mechanisms and Potential Therapeutics. Biomedicines. 2023; 11(8):2275. doi: 10.3390/biomedicines11082275.

Speidell A, Walton S, Campbell L, Tessarollo L, Tomassoni-Ardoni F, Corbo C, Taraballi F, Mocchetti I. Mice deficient for G-protein coupled receptor 75 display altered presynaptic structural protein expression and disrupted fear conditioning recall. J Neurochem. 2023;165:827-841. PMID: 36978267

Speidell A. Investigation of the role of the p75 neurotrophin receptor in HIV-1 gp120-associated synaptic and neural injury. [Doctoral dissertation] Georgetown University, Washington, DC. (2023)

Downey RM, Downey KB, Jacobs J, Korthas H, Melchor GS, Speidell A, Waguespack H, Mulroney SE, Myers AK. Learning design in science education: perspectives from designing a graduate-level course in evidence-based teaching of science. Adv Physiol Educ. 2022 Dec 1;46(4):651-657. doi: 10.1152/advan.00069.2022. Epub 2022 Sep 29. PMID: 36173341.

Speidell A and Mocchetti I. The p75 neurotrophin receptor: emerging role in the pathogenesis of mature synapses in Human Immunodeficiency Virus-Associated Neurocognitive Disorders. HIV-Associated Neurocognitive Disorders. (2023)

Asuni GP, Speidell A, Mocchetti I. Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor. J Neurochem. 2021 Jul;158(2):169-181. doi: 10.1111/jnc.15355. Epub 2021 Apr 12. PMID: 33742683.

Speidell A, Asuni GP, Wakulski R, Mocchetti I. Up-regulation of the p75 neurotrophin receptor is an essential mechanism for HIV-gp120 mediated synaptic loss in the striatum. Brain Behav Immun. 2020 Oct;89:371-379. doi: 10.1016/j.bbi.2020.07.023. Epub 2020 Jul 24. PMID: 32717404; PMCID: PMC7572812.

Speidell A, Asuni GP, Avdoshina V, Scognamiglio S, Forcelli P, Mocchetti I. Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor. Front Cell Neurosci. 2019 Aug 30;13:398. doi: 10.3389/fncel.2019.00398. PMID: 31543761; PMCID: PMC6730486.

Wenzel ED, Speidell A, Flowers SA, Wu C, Avdoshina V, Mocchetti I. Histone deacetylase 6 inhibition rescues axonal transport impairments and prevents the neurotoxicity of HIV-1 envelope protein gp120. Cell Death Dis. 2019 Sep 12;10(9):674. doi: 10.1038/s41419-019-1920-7. PMID: 31515470; PMCID: PMC6742654.

Speidell AP, Demby T, Lee Y, Rodriguez O, Albanese C, Mandelblatt J, Rebeck GW. Development of a Human APOE Knock-in Mouse Model for Study of Cognitive Function After Cancer Chemotherapy. Neurotox Res. 2019 Feb;35(2):291-303. doi: 10.1007/s12640-018-9954-7. Epub 2018 Oct 4. PMID: 30284204; PMCID: PMC6333492.

Speidell A. The Effect of Cirazoline and Clonidine on the Firing Rates of Thermoclassified Neurons in the Anterior Hypothalamus. [Honors thesis] The College of William and Mary, Williamsburg, Virginia (2008).

Imbery TE, Irdmusa MS, Speidell AP, Streer MS, Griffin JD. The effects of Cirazoline, an alpha-1 adrenoreceptor agonist, on the firing rates of thermally classified anterior hypothalamic neurons in rat brain slices. Brain Res. 2008 Feb 8;1193:93-101. doi: 10.1016/j.brainres.2007.12.016. Epub 2007 Dec 15. PMID: 18184607; PMCID: PMC2268753.

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